Ketogenic Diet Shows Promise in Improving Serious Mental Illness Symptoms

The keto diet emerges as a promising complementary treatment, improving metabolic markers and reducing psychiatric symptoms in those with severe mental illness.
Ketogenic Diet Shows Promise in Improving Serious Mental Illness Symptoms
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George Citroner
4/17/2024
Updated:
4/24/2024
0:00

A pilot study has uncovered an unlikely ally in the fight against serious mental illness.

The ketogenic diet, long touted for its weight-loss benefits, may be vital in tackling both the physical and psychiatric symptoms plaguing those living with schizophrenia and bipolar disorder.

Reversing Antipsychotic-Induced Metabolic Issues

Antipsychotic medications can lead to metabolic side effects such as insulin resistance and obesity, causing many patients to discontinue treatment. However, new research from Stanford University suggests that the ketogenic diet could be a powerful aid in treating mental illness.
The study, published in Psychiatry Research, followed 21 adults with schizophrenia or bipolar disorder taking antipsychotics and experiencing metabolic abnormalities. Participants followed a ketogenic diet of 10 percent carbs, 30 percent protein, and 60 percent fat. Researchers tracked the participants’ progress by measuring their blood ketone levels weekly, which indicates whether the body is burning fat for fuel.

After four months, none met the criteria for metabolic syndrome, and they had lost 10 percent of their body weight on average, reporting improved energy, sleep, mood, and quality of life. Participants also showed significant enhancements in markers such as blood pressure, body mass index, triglycerides, and insulin resistance.

“We’re seeing huge changes,” Dr. Shebani Sethi, a clinical professor of psychiatry at Stanford Medicine and lead author of the study, said in a statement. Despite patients being on antipsychotic medications, the issues of obesity, metabolic syndrome, and insulin resistance can still be effectively addressed and reversed.

“I think that’s very encouraging for patients,” she noted.

Significant Psychiatric Benefits

The participants showed significant psychiatric benefits as well. On average, they improved by 31 percent on a clinician-rated mental illness severity scale known as the Clinical Global Impressions scale. It is a seven-point clinician-rated measure of mental illness severity, ranging from 1 (normal) to 7 (extremely severe).

In fact, 75 percent of the group demonstrated clinically meaningful improvement.

The ketogenic diet may provide an alternative fuel source for the brain, helping improve brain metabolism and reduce mental illness symptoms, according to the research team.

Nutrition should be a first-line approach for addressing mood and cognitive symptoms in general, Nicole Laurent, a licensed mental health counselor who specializes in using ketogenic therapy to treat mental illness and neurological issues (although she was not involved in this study), told The Epoch Times.

“We should be evaluating people’s diets to ensure they are getting the most basic things their brain needs to work well before we decide that something is broken,” Ms. Laurent said.

Why Diet Affects Mental Health

Diet can greatly affect mood and mental well-being for several reasons, Sanam Hafeez, a neuropsychologist in New York City and director of Comprehend the Mind, told The Epoch Times.

A balanced diet provides the brain with essential vitamins, minerals, and nutrients needed for optimal function. The types of foods we consume affect our blood sugar levels, and rapid fluctuations can lead to mood swings and irritability, according to Ms. Hafeez.

“Sticking to a balanced diet can stabilize our blood sugar levels, promoting sustained energy and a more consistent mood,” she said.

Certain foods can trigger inflammation, contributing to mood disorders such as depression and anxiety.

“Opting for an anti-inflammatory diet, rich in whole foods and healthy fats, may help reduce inflammation and support mental health,” Ms. Hafeez said.

Food allergies or sensitivities can also cause mood disturbances. Identifying and avoiding these “trigger foods” can effectively manage these symptoms, she said.

It’s essential to be mindful of caffeine and alcohol consumption, as excessive intake can disrupt sleep patterns and exacerbate mood fluctuations and anxiety.

Possible mechanisms behind the diet’s mental health benefits include reducing inflammation, improving metabolism and the gut microbiome, and addressing nutritional deficiencies linked to changes in mood and cognition, according to Genna Hymowitz, a psychologist at the Stony Brook Medicine Bariatric and Metabolic Weight Loss Center.

Evidence for the Effect of Specific Diets on Mental State

It’s challenging to definitively prove that specific diets lead to changes in mental health, Ms. Hymowitz told The Epoch Times. However, research has suggested associations between dietary intake and mental health, she noted.
Studies have linked diets high in fruits, vegetables, fish, and whole grains to better mental health and decreased likelihood of depression. Similarly, the Mediterranean diet has been associated with a reduced risk of depression and improvements in depression symptoms.

The ketogenic diet has previously been recommended for treating severe epilepsy, a neurological disorder causing seizures, particularly in children whose seizures did not respond to medication, according to Ms. Hymowitz.

A 2019 review of studies concluded that the ketogenic diet may be a novel therapeutic approach for treating schizophrenia, potentially by restoring brain energy metabolism.
George Citroner reports on health and medicine, covering topics that include cancer, infectious diseases, and neurodegenerative conditions. He was awarded the Media Orthopaedic Reporting Excellence (MORE) award in 2020 for a story on osteoporosis risk in men.
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