Innovative Therapy Protects Blood-Brain Barrier, Has Potential to Alleviate Brain Fog: Study

A recent animal study showed a gene therapy treatment may reduce white blood cell buildup in the brain, which contributes to brain fog.
Innovative Therapy Protects Blood-Brain Barrier, Has Potential to Alleviate Brain Fog: Study
(Billion Photos/Shutterstock)
Ellen Wan
4/15/2024
Updated:
4/15/2024
0:00

After recovering from COVID-19, many people experience memory issues and learning difficulties, commonly known as brain fog. A recent study explored the mechanisms behind virus-induced brain fog and potential treatment methods.

In February, researchers from the University of Illinois–Chicago published a study in the journal Brain on the mechanisms of neurological disorders in mice infected with SARS-CoV-2, the virus that causes COVID-19, along with preliminary treatment methods.

After contracting the COVID-19 virus, patients’ cerebrovascular endothelial cells become inflamed, damaging the blood-brain barrier. This allows macromolecules and white blood cells in the blood to leak uncontrollably into the brain tissue. The disruption of the blood-brain barrier can result in neuroinflammation and cognitive impairment, contributing to neurological diseases such as multiple sclerosis.

The researchers examined the brain vasculature of mice infected with the COVID-19 virus and found blood-brain barrier leakage, which affected memory or learning abilities. They also discovered that the COVID-19 virus disrupted the Wnt/beta-catenin signaling pathway in brain endothelial cells, which plays a vital role in regulating blood-brain barrier function. The term “signaling pathway” refers to a series of chemical reactions within a cell triggered by external signal molecules, such as the Wnt protein.

The researchers used gene therapy to enhance the Wnt/beta-catenin signaling pathway in brain vasculature, thereby protecting the blood-brain barrier. The results showed a significant reduction in the accumulation of white blood cells in the brains of treated mice, indicating that white blood cells were no longer flowing into the brain from the blood. Additionally, the mice exhibited improvements in learning and memory abilities.

Sarah E. Lutz, the lead researcher, stated in a press release that while this treatment method is still a long way from being applied in humans, the research has taken an important step. By identifying the molecular mechanisms that cause a disease, we can understand the fundamental biological processes and the causes of disease in general.

Dr. Jalees Rehman, a co-author of the study and head of the Department of Biochemistry and Molecular Genetics at the University of Illinois–Chicago, stated in the press release that the COVID-19 pandemic has shown us that even mild infections can harm organs, such as the brain. He believes that more research is needed on respiratory infections that may affect the brain and that understanding the molecular signals activated by infection and during inflammatory responses may help us discover new targeted therapies.

Older People at Higher Risk of Brain Damage From Infection

A study published in Nature Neuroscience in February found that both patients with acute COVID-19 infection and those who developed brain fog as a complication after infection exhibited evident disruption to the blood-brain barrier.

The researchers analyzed serum and plasma samples from 76 hospitalized patients infected with the COVID-19 virus, comparing them with 25 samples collected before the pandemic. The results showed significant differences in serum and plasma samples between the mild, moderate, and severe patients and the control group.

In serum samples from COVID-19 patients with brain fog, the protein S100-beta is notably elevated. When present in high levels in the serum, this protein typically serves as a marker of blood-brain barrier dysfunction. Older patients exhibit relatively higher levels of S100-beta protein in their serum, indicating that older people are more susceptible to blood-brain barrier damage following COVID-19 infection.

A Psychiatrist’s 4 Recommendations

Dr. Mak Kai Lok, a psychiatrist in Hong Kong, told The Epoch Times that most brain fog can be gradually improved through diet and exercise. However, he added that for older individuals who experience severe memory decline after infection, it is essential to be cautious about possible brain degeneration and seek timely medical attention.
Dr. Mak offers the following advice for patients with brain fog:
  • Get plenty of rest.
  • Exercise regularly, as it promotes oxygen delivery to the brain through the bloodstream.
  • Eat more fresh fruits and vegetables, as their antioxidant content can help eliminate waste from the brain.
  • Take brain supplements that have been medically proven, and take them in appropriate doses.

Improving Symptoms With Acupressure and Diet Therapy

Shih Cheng-Hsiu, a Taiwanese traditional Chinese medicine (TCM) practitioner and the director of Shih Cheng-Hsiu Chinese Medicine Clinic, stated on a television program that COVID-19 patients with brain fog can restore physical strength and improve symptoms through acupressure and diet therapy.

Mr. Shih noted that patients with brain fog often experience poor sleep quality, which hinders proper rest and leads to a decline in physical strength. In such cases, taking Danggui Buxue Tang every morning can help improve cardiopulmonary function and restore physical strength.

Ingredients:
  • 0.11 ounce (3 grams) Angelica sinensis (Danggui)
  • 0.53 ounce (15 grams) Astragalus (Huangqi)
Preparation:

After cleaning the ingredients thoroughly, place them in a covered cup, pour boiling water over them, steep for 15 minutes, and then drink.

This tea is best consumed in the morning and is not recommended for evening consumption. It is also not suitable for women during menstruation.

Research has found that Angelica sinensis has antioxidant, immunoregulatory, and hematopoietic (blood cell-building) properties, which can help improve cardiovascular and cerebrovascular diseases, neurological disorders, and kidney diseases. Studies have also shown that Astragalus can protect neurons and improve memory.

Patients experiencing brain fog often report neck tightness and poor blood circulation. Massaging the Fengchi acupoint below the occipital bone can help gradually relax the tense area.

The Fenchi point. (The Epoch Times)
The Fenchi point. (The Epoch Times)

Additionally, brain fog patients often suffer from scalp tightness and may even develop bumps. Regular scalp massages are recommended. Another option is to use a scraping board to scrape the scalp. Although it may cause discomfort, it can leave you feeling refreshed and invigorated afterward.

Some herbs mentioned in this article may be unfamiliar, but they are generally available in health food stores and Asian grocery stores. Treatment methods may vary depending on the individual. Please consult a health care professional for a specific treatment plan.

Ellen Wan has worked for the Japanese edition of The Epoch Times since 2007.
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