While there is some scientific evidence to suggest they can help manage diabetes, promote liver and lung health, reduce inflammation, and support the immune system, they are mostly known for their potential to fight cancer.
1. Lion’s Mane
Found in temperate regions of the Northern Hemisphere, Lion’s manes are best known for their potential to support brain health. They have antidepressant qualities that could be beneficial in reducing brain damage following stroke, and they may be helpful in preventing brain degeneration.2. Reishi
Most commonly found in Asia, reishi is best known for its immune-boosting and anti-cancer properties. While the reishi mushroom remains popular in Eastern medicine, there are few human studies on the effects of this mushroom.3. Turkey Tail
Routinely used by doctors in Japan and China, turkey tail is best known for its use in traditional Chinese medicine as an anti-cancer agent.4. Shiitake
Native to Southeast Asia, shiitake is broadly used in Japan for the treatment of cancers, particularly stomach cancer. Evidence supports that Lentinan, a polysaccharide extracted from the mushroom, may support some cancers when used in conjunction with chemotherapy.Laboratory testing indicates that lentinan improves a number of aspects of the immune system, which may help slow tumor growth. Research through clinical trials demonstrated that lentinan was effective in extending survival in patients with stomach, pancreatic, colorectal, and liver cancers.
5. Maitake
Routinely used by doctors in Japan and China, maitake is best known for its effects on the immune system.This mushroom is known as an adaptogen. Adaptogens help the body fight chemical, physical, or biological stress. In other words, they stimulate your body’s immune system.
6. Chaga
Native to the cooler northern regions of Europe, Asia, and North America, chaga is best known for its anti-cancer and immunity boosting properties. Grown on birch trees, chaga pulls the nutrients and extracts from the inner layers of the bark, which are thought to be betulinic acid, sterols, and polysaccharides and which have demonstrated repressive effects against colon cancer and hepatoma cells.Is there a difference between regular and medicinal mushrooms?
There’s no clear division between the two. Culinary mushrooms, such as portobello and shiitake, are mainly used in cooking because they have a pleasant taste. Many medicinal mushrooms, on the other hand, are known to have a more bitter taste and are predominantly used as a supplement to achieve various health benefits.
You probably noticed that the shiitake mushroom is considered both a medicinal mushroom and a culinary mushroom. So, does that mean all culinary mushrooms contain immune-boosting compounds too? Research suggests that they do. But it’s important to remember that each mushroom varies in their dosing ratio and their individual effect on human health and wellness.
As with any other supplement, it’s critical that you seek the advice of your primary care provider, especially the ones with a background in herbal medicine or medicinal mushrooms, before adding any supplement to your daily routine. Your physician will evaluate your personal health and help you determine if you could benefit from medicinal mushrooms and if so, which ones would best support your personal health goals.
Wasser SP. Medicinal Mushrooms in Human Clinical Studies. Part I. Anticancer, Oncoimmunological, and Immunomodulatory Activities: A Review. Int J Med Mushrooms. 2017;19(4):279-317. doi: 10.1615/IntJMedMushrooms.v19. i4.10. PMID: 28605319.
Venturella G, Ferraro V, Cirlincione F, Gargano ML. Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials. Int J Mol Sci. 2021 Jan 10;22(2):634. doi: 10.3390/ijms22020634. PMID: 33435246; PMCID: PMC7826851.
Wasser SP. Medicinal mushroom science: Current perspectives, advances, evidences, and challenges. Biomed J. 2014 Nov-Dec;37(6):345-56. doi: 10.4103/2319-4170.138318. PMID: 25179726.
Stamets P, Zwickey H. Medicinal Mushrooms: Ancient Remedies Meet Modern Science. Integr Med (Encinitas). 2014 Feb;13(1):46-7. PMID: 26770081; PMCID: PMC4684114.
Wong KH, Naidu M, David P, Abdulla MA, Abdullah N, Kuppusamy UR, Sabaratnam V. Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae). Evid Based Complement Alternat Med. 2011; 2011:580752. doi: 10.1093/ecam/neq062. Epub 2011 Aug 11. Erratum in: Evid Based Complement Alternat Med. 2018 Dec 16; 2018:9820769. PMID: 21941586; PMCID: PMC3176599.
Lai PL, Naidu M, Sabaratnam V, Wong KH, David RP, Kuppusamy UR, Abdullah N, Malek SN. Neurotrophic properties of the Lion’s mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. Int J Med Mushrooms. 2013;15(6):539-54. doi: 10.1615/intjmedmushr. v15.i6.30. PMID: 24266378.
Science Direct. Chapter 21 - Endophytic Fungi as a New Source of Antirheumatoid Metabolites.
Lai PL, Naidu M, Sabaratnam V, Wong KH, David RP, Kuppusamy UR, Abdullah N, Malek SN. Neurotrophic properties of the Lion’s mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. Int J Med Mushrooms. 2013;15(6):539-54. doi: 10.1615/intjmedmushr. v15.i6.30. PMID: 24266378.
Ahmad R, Riaz M, Khan A, Aljamea A, Algheryafi M, Sewaket D, Alqathama A. Ganoderma lucidum (Reishi) an edible mushroom; a comprehensive and critical review of its nutritional, cosmeceutical, mycochemical, pharmacological, clinical, and toxicological properties. Phytother Res. 2021 Nov;35(11):6030-6062. doi: 10.1002/ptr.7215. Epub 2021 Aug 19. PMID: 34411377.
Benson KF, Stamets P, Davis R, Nally R, Taylor A, Slater S, Jensen GS. The mycelium of the Trametes versicolor (Turkey tail) mushroom and its fermented substrate each show potent and complementary immune activating properties in vitro. BMC Complement Altern Med. 2019 Dec 2;19(1):342. doi: 10.1186/s12906-019-2681-7. PMID: 31791317; PMCID: PMC6889544.
Dai X, Stanilka JM, Rowe CA, Esteves EA, Nieves C Jr, Spaiser SJ, Christman MC, Langkamp-Henken B, Percival SS. Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults. J Am Coll Nutr. 2015;34(6):478-87. doi: 10.1080/07315724.2014.950391. Epub 2015 Apr 11. PMID: 25866155.
Soares R, Meireles M, Rocha A, Pirraco A, Obiol D, Alonso E, Joos G, Balogh G. Maitake (D fraction) mushroom extract induces apoptosis in breast cancer cells by BAK-1 gene activation. J Med Food. 2011 Jun;14(6):563-72. doi: 10.1089/jmf.2010.0095. Epub 2011 Apr 11. PMID: 21480800.
Park YK, Lee HB, Jeon EJ, Jung HS, Kang MH. Chaga mushroom extract inhibits oxidative DNA damage in human lymphocytes as assessed by comet assay. Biofactors. 2004;21(1-4):109-12. doi: 10.1002/biof.552210120. PMID: 15630179.